Friday, November 8, 2019

Recent Advancements in Drug Delivery: Novel Drug Formulations & Technologies:




The pharmaceutical and biotechnology industries have come a long way when it comes to advancements in drug discovery. New “druggable” targets and mechanistic approaches to treating even complex diseases are constantly discovered and optimized, generating a rich pipeline and continuous supply of fresh therapeutics for difficult diseases, such as autoimmune inflammatory disorders (for example, rheumatoid arthritis, inflammatory bowel disease), cancer, hepatitis C, and other infectious diseases, as well as neurological conditions.


However, developing a safe and effective drug is only part of the picture – perfecting the delivery of that drug into the patient is also a significant aspect of the total pharmacotherapeutic regimen. It is generally accepted by the pharmaceutical industry that the oral route of delivery is most preferred by the patient. For example, biologicals, such as vaccines or therapeutic antibodies, typically must be injected directly into the bloodstream because oral ingestion would result in the destruction of the fragile protein composition. Also, orally administered drugs tend to be distributed systemically, whereas the diseased portion of the body may be localized to a single organ or tissue. Thus, oral administration and systemic distribution may result in unnecessary exposure to the drug and unwanted side effects that could potentially be avoided with targeted drug delivery and isolation at the source of disease.




Recent Developments in Injectable Drug Delivery:



Products like tumor necrosis factor (TNF) inhibitors for rheumatoid arthritis or glucagon-like peptide-1 (GLP-1) analogs for diabetes offer patients true disease-modifying benefits as opposed to simply treating the symptoms, and these benefits generally, outweigh the discomfort associated with the injection. All other things being equal, subcutaneous is generally the preferred injectable route as it can be easily performed by the patient at home using delivery devices, such as auto-injectors or pen injectors. However, even with the most sophisticated pen injectors, it still may be considered an unpleasant experience by many patients.


Tailoring the delivery of injectable drugs is mainly dependant on the specifics of two parameters: formulation and device. When the injection is a necessity, new delivery technologies can improve the experience in several ways.  Detailing upgrades can decrease the recurrence of the administration, lessen the volume required for every infusion, or diminish reactions related to the definition, for example, immunogenicity. Delivery device improvements, for example, a smaller needle or auto-injectors that improve ease of self-infusion, can fundamentally improve the patient experience. Although the pharmaceutical industry makes many attempts to move away from injectable administration, injectable drugs continue to fill the development pipeline as demonstrated in Figures 2 and 3.



Several companies are making great strides in improving the patient experience of self-injection which resembles an adhesive patch rather than a typical pen injector. It will be like a disposable pump that slowly delivers a subcutaneous dose of medication over a period ranging from 5 seconds to 24 hours and can deliver volumes up to 5 milliliters. Rather than having to perform self-injection by pinching the skin and holding a pen injector in place, the patient simply adheres to this pump-patch to a suitable location, such as the abdomen, and, with the press of a button, the device slowly injects the medication. In addition to improving ease of use, the slow delivery also reduces trauma and discomfort associated with the injection of larger volumes because the drug is allowed to slowly scatter instead of framing a pocket underneath the skin. Because the device uses hydraulic power of an expandable gel to drive the injection, the shelf life and utility are greatly enhanced compared to a device that relies on battery power. This device could be used with any drug with no need to reformulate, and even high-viscosity formulations can be successfully delivered.


For more information, go through the link: https://pharma.pharmaceuticalconferences.com/

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Friday, October 25, 2019

Advancements in Drug Delivery Systems: Novel Technologies & Formulations




Targeting the drugs to specific organs and tissues has become one of the critical goals as the use of conventional dosage forms do not help in achieving the desired concentration at the target site during a proper time period. Discovery of new drug delivery systems is one of the growing research areas. The recently discovered new drug delivery systems include lipid, protein and polymer technologies with better lipid distribution in the body, prevention of drug degradation from external environment and reduced rate of drug clearance. This review article is about the latest advancements in drug delivery systems and novel technologies and formations produced to achieve the desired drug delivery.



The method of drug delivery plays a very crucial role on its therapeutic efficacy. Some drugs have low therapeutic index which have an optimum concentration range within which maximum therapeutic benefit is achieved and drug concentrations above or below this optimum range can be dangerous or produce no therapeutic benefit. Some drugs on other hand have a high therapeutic index and require higher concentrations of drugs to be used to produce maximum therapeutic benefit and these results in toxic effects. So under all these cases targeting the drugs to specific organs and tissues has become one of the critical goals as the use of conventional dosage forms do not help in achieving the desired concentration at the target site during a proper time period




The new drug delivery systems are discovered with the aim to resolve solubility problems, prevent external environment issues on the drug such as photodegradation and pH changes, make the drug more lipid soluble so that it can easily cross lipid barriers in the body and achieve desired concentration at the desired location for maximum therapeutic effect. Moreover, sustained and controlled targeting at the site of action and reduced time of exposure of non-targeted tissues increases the drug efficacy and reduces side effects and thus improves patient compliance towards the drugs. Currently, a number of new drug delivery systems are currently under investigation to overcome the limitations of the conventional dosage forms and improves the therapeutic efficacy and potency of the drug 

The therapeutic benefits of the new drug delivery systems include
• Increased efficacy of the drug
• Site-specific delivery
• Reduced side effects
• Increased patient compliance & convenience
• Reduced healthcare costs
  

New Drug Carriers Systems
There are several new drug carriers in the market which are being used and several others are under process of clinical trials and several others are being discovered by researchers and scientists for giving maximum benefits to the patients.

Some of the novel drug delivery systems include:

1. Transdermal Drug Delivery Systems
2. Colloidal Drug Carrier Systems
  •        Liposomal delivery systems
  •         Nanoparticulate delivery systems
  •         Micelles
  •         Dendrimers


3. Variable Release Delivery Systems
4. Implantable Delivery Systems
5. Nasal Delivery Systems

Approaches for Achieving the Desired Systems:

There are several approaches used for achieving the desired form of delivery systems. Some of the Major approaches include:
1. Sustained Release Systems
2. Controlled Release Systems
  •        Reservoir Systems
  •         Monolithic Systems
  •         Laminated Systems
  •         Chemical Systems

3. Targeted Drug Delivery Systems
  •         Local Targeted Delivery
  •         Differential Metabolism Approach
  •         Biological Recognition
  •         Biophysical Approach
  •         Prodrugs
4. Pulsatile Delivery Systems


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Friday, October 18, 2019

5 Positives Influencing Clinical Trials





Clinical preliminaries have turned out to be progressively expensive endeavors, adding to the general expense of building up medication and, at last, the value that patients pay for medications.
Enormous pharma's and little biotech’s the same are searching for inventive approaches to improve preliminary results and, thus, lower preliminary expenses — this implies expanding the proficiency wherein they enroll patients, observing all the more intently how medications are provided and being increasingly adaptable about preliminary plan.

 1. Patient centricity:

Patient centricity has obviously been one of the huge buzz inside the business over the  couple of years. This hot topic is now part of clinical trials as well.
Patients are also forming more support groups to discuss their disease and available treatments and these support groups often continue past the trial.

 2. Tapping into technology:

 Pharma and biotechs are using mobile messaging to increase patient recruitment ahead of trials and then keep patients on track during clinical trials. Few Companies have shown that using mobile platforms increases patient recruitment by 30% and can reduce the cost of trials. Mobile apps can also remind patients about appointments when to take drugs and even provide instructions.

3. Data you can wear:

Expanding on the idea of using technology in clinical trials, there is a movement to have patients bring their own devices. While patients may be more comfortable with their own devices, there are still concerns about how secure the data may be and what happens if a patient loses their device.
Clinicians and pharma’s are also tapping into the use of wearables to get better patient data since the device can be with patients at all times.

4. Flexibility:

The company was able to adjust the endpoints and increase the number of patients in its Phase 3 trial for its immunotherapy. While the results will be delayed, the British company believes the new adjustments to the clinical trial will give durvalumab the best chance of succeeding, either as a combination or a monotherapy.



5. Automated site supplies:

Some pharma and biotech companies have begun to use computer-controlled supply systems to automate drug dispensing and manage site inventories. The practice is becoming more common because it allows for less waste within the supply chain and gives companies a tighter handle on the amount of drug used.


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Friday, October 11, 2019

Is Novel Drug Delivery System responsible for the Enhanced Drug Delivery?



Novel Drug Delivery System comprising the methods namely

  •        Transdermal Drug Delivery system
  •        Carrier Based Drug delivery system


Both the methods have been a revolution in the field of drug delivery and distribution. The aspects like bioavailability of the drug to the body and specificity of the target in body has been optimized by the improvements and discoveries made in the field of novel drug delivery system.
Targeted drug delivery system has been the major motto of the NDDS from the very start of the subject inclusion as a result many wonders are been discovered year by year which is leading to the optimized and enhanced mechanism of drug distribution and delivery with specificity in the target  


Transdermal Drug Delivery System

|| Sonophoresis

  •        Mucoadhesive Delivery System
  •        Supramolecular Delivery System
  •        Variable Release Delivery System



|| Osmatic Pump


|| Microencapsulation


Transdermal Drug delivery system has been the major aspect to be discussed that had given the release from the administration of pain killers which are leading to drug abuse. The transdermal drug delivery patches have been the major development which later have been used not only as pain killers or analgesics but also many other targeted drug administrations.

Pros: No dose dumping, No internal administration, no drug drug interactions.

Cons: Dermal infections.

Carrier Based Drug Delivery System

  • Liposomes
  • Nanoparticles
  • Microspheres
  • Resealed Erythrocytes
  • Monoclonal Antibodies


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                                                    pharmaconference2k19@gmail.com

Friday, October 4, 2019

Is there any recent advancement in Pharmacy Research?




Pharmacy is the science and strategy of planning and dispensing drugs. It may be a health profession that joins the health sciences with chemical sciences and points to ensure the safe and effective utilization of pharmaceutical drugs. The scope of pharmacy practice incorporates more conventional parts such as compounding and dispensing medications, and it too incorporates more advanced administrations related to health care, including clinical administrations, reviewing medicines for security and adequacy, and providing drug data. Pharmacists, subsequently, are the specialists on medicating therapy and are the essential health experts who optimize the use of a pharmaceutical for the advantage of the patients.

The field of pharmacy can generally be partitioned into three essential disciplines: Pharmaceutical Sciences, Medicinal Chemistry and Pharmacognosy, Pharmacy Practice. The boundaries between these disciplines and with other sciences, such as biochemistry, are not continuously clear-cut. Regularly, collaborative groups from different disciplines (pharmacists and other researchers) work together toward the presentation of unused therapeutics and strategies for understanding care. In any case, the pharmacy isn't an essential or biomedical science in its ordinary form. Medicinal chemistry is additionally an unmistakable department of synthetic chemistry combining pharmacology, natural chemistry, and chemical biology.




Scope of Pharmacy Profession

ü  Hospital Pharmacy
ü  Clinical Pharmacy
ü  Ambulatory Care Pharmacy
ü  Compounding Pharmacy
ü  Consultant Pharmacy
ü  Internet Pharmacy
ü  Pharmacy Informatics
ü  Military Pharmacy

Roles and Responsibilities

ü  Good Communication skills
ü  Counselling Skills
ü  Interpersonal Skills
ü  Leadership Skills
ü  Scientific Aptitude
ü  Computer skills

Conclusion:

In addition pharmacists involve in direct patient care and are taking responsibility for the resolution of drug therapy problems of individuals.


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Friday, September 27, 2019

Facts on Pharmacovigilance



Pharmacovigilance, or in simple terms drug safety, is a medicinal science which involves the research and prevention of reactions which may take place following the administration of pharmaceutical medication or devices. As such, one of the main topics of importance in the science is Adverse Drug Reactions. ADR, as the name infers, is the unexpected response in a body which may occur upon the utilization of pharmaceutical items. Pharmacovigilance is a serious health issue that can potentially affect entire populations, and is therefore overseen by the WHO in association with medical institutions throughout the world.

PV Deals With???

PV is the study of gathering, observing, examining, surveying and assessing data from social insurance suppliers and patients on the unfriendly impacts of drugs, organic items, blood items, herbals, immunizations, therapeutic gadget, conventional and integral prescriptions with the end goal of recognizing new data about dangers related with items and avoiding damage to patients. The test of boosting drug security and keeping up open certainty has turned out to be progressively perplexing. Pharmaceutical and biotechnology organizations must screen, yet in addition proactively gauge and oversee sedate hazard all through an item's lifecycle, from improvement to post-advertise ADR Suspicion.


Scope of PV

Today the extent of PV incorporates issues identified with:
- Herbal, conventional and complimentary medications.
- Blood items, biologicals, restorative gadgets and antibodies.
- Substandard and fake medications.
- Medication blunders and unreasonable utilization of prescriptions.
- Antimicrobial obstruction.

Mechanism of Action

As mentioned earlier, there can be various causes of ADR which are not so easily unearthed. Various methods have been formed to help assess the occurrence and causation of an ADR and whether it is to be reported to the local authorities. This includes the Venulet Algorithm and the Naranjo Algorithm. It is given, be that as it may, that no report of ADR is documented without the test dechallenge-rechallenge, which essentially implies that the medication is ceased and restarted to check the connection between the responses and the medicines.

Conclusion

The unfriendly occasions detailed by PV framework will conceivably profit to the network because of their closeness to both the populace and general wellbeing experts, as far as language and learning of the way of life and propensities for patients, empowers simple contact with journalists, for instance by phone, Email, content back rubs by cell phones. The improvement of new and viable therapeutic items makes a positive commitment to the wellbeing and prosperity of people. Be that as it may, there is a need to improve PV frameworks to all the more adequately screen and make a move on wellbeing issues related with medications to upgrade their commitment to general wellbeing.

Friday, August 23, 2019

INITIAL ANNOUNCEMENT OF 2nd MIDDLE EAST PHARMACY AND PHARMACEUTICAL CONFERENCE






Pharmacy is the science and strategy of planning and dispensing drugs. It may be a health profession that joins the health sciences with chemical sciences and points to ensure the safe and effective utilization of pharmaceutical drugs. The scope of pharmacy practice incorporates more conventional parts such as compounding and dispensing medications, and it too incorporates more advanced administrations related to health care, including clinical administrations, reviewing medicines for security and adequacy, and providing drug data.
ME Conferences take privilege to welcomes you to attend 2nd Middle East Pharmacy and Pharmaceutical Conference scheduled to be held during December 09-10, 2019 at Dubai, UAE with the theme “Innovative Researches and Developments in Pharmaceutical Sciences”.
Pharma Conference 2019 forecasts existence of keynote speeches, session speeches, delegates, young researchers and students around the world. This conference perhaps a giant event that creates an ideal platform to share expertise addressing current advancements involved in Pharmaceutical Sciences and Pharmaceutical Technology. It will be a wonderful opportunity for all the delegates as it provides an international networking opportunity to collaborate with the world class pharma associations and societies.

   Target Audience:
·        Pharmaceutical Researchers
·        Professors and Associate Professors
·        Directors and CEO’s of Organizations
·        Pharmaceutical societies, Associations
·        Physicians and clinical pharmacists
·        Pharmacologists
·        Nanotechnologists
·        Pharmaceutical societies
 Conference Sessions:
  •        Pharmaceutical Sciences
  •        Pharmacy
  •      Novel Drug Delivery Systems
  •        Pharmacology and Toxicology
  •       Biologic and Biosimilar
  •        Pharmaceutical Technology
  •        Drug Discovery and Design
  • ·      Bioavailability and Bioequivalence
  •        Clinical Research  and Clinical Trials
  •        Pharmacognosy and Phytochemistry
  •        Pharmaceutical Care
  •       Drug Formulation & Analytical Techniques
  •       Recent trends in Pharma and Technology
  •        Clinical Pharmacy
  •        Pharma Pricing and Market Research

·       Pharmacovigilance & Regulatory Affairs

Book Mark your Dates for 2nd Middle East Pharmacy and Pharmaceutical Conference in Dubai, UAE for more recent updates in Pharmaceutical Sciences  and Pharmaceutical Technology.






Recent Advancements in Drug Delivery: Novel Drug Formulations & Technologies:

The pharmaceutical and biotechnology industries have come a long way when it comes to advancements in drug discovery. New “druggable”...