Targeting the drugs to specific organs and
tissues has become one of the critical goals as the use of conventional dosage
forms do not help in achieving the desired concentration at the target site
during a proper time period. Discovery of new drug delivery systems is one of
the growing research areas. The recently discovered new drug delivery systems
include lipid, protein and polymer technologies with better lipid distribution in
the body, prevention of drug degradation from external environment and reduced
rate of drug clearance. This review article is about the latest advancements in
drug delivery systems and novel technologies and formations produced to achieve
the desired drug delivery.
The method of drug delivery plays a very
crucial role on its therapeutic efficacy. Some drugs have low therapeutic index
which have an optimum concentration range within which maximum therapeutic
benefit is achieved and drug concentrations above or below this optimum range
can be dangerous or produce no therapeutic benefit. Some drugs on other hand
have a high therapeutic index and require higher concentrations of drugs to be
used to produce maximum therapeutic benefit and these results in toxic effects.
So under all these cases targeting the drugs to specific organs and tissues has
become one of the critical goals as the use of conventional dosage forms do not
help in achieving the desired concentration at the target site during a proper
time period
The new drug delivery systems are
discovered with the aim to resolve solubility problems, prevent external
environment issues on the drug such as photodegradation and pH changes, make
the drug more lipid soluble so that it can easily cross lipid barriers in the
body and achieve desired concentration at the desired location for maximum
therapeutic effect. Moreover, sustained and controlled targeting at the site of
action and reduced time of exposure of non-targeted tissues increases the drug
efficacy and reduces side effects and thus improves patient compliance
towards the drugs. Currently, a number of new drug delivery systems are
currently under investigation to overcome the limitations of the conventional
dosage forms and improves the
The therapeutic benefits of the new drug
delivery systems include
• Increased efficacy of the drug
• Site-specific delivery
• Reduced side effects
• Increased patient compliance &
convenience
• Reduced healthcare costs
New Drug Carriers Systems
There are several new drug carriers in the market which are being used
and several others are under process of clinical trials and several others are being discovered by researchers and
scientists for giving maximum benefits to the patients.
Some of the novel drug delivery
systems include:
1. Transdermal Drug Delivery Systems
2. Colloidal Drug Carrier Systems
- Liposomal delivery systems
- Nanoparticulate delivery systems
- Micelles
- Dendrimers
3. Variable Release Delivery Systems
4. Implantable Delivery Systems
5. Nasal Delivery Systems
Approaches for Achieving the
Desired Systems:
There are several approaches used for achieving the desired form of
delivery systems. Some of the Major approaches include:
1. Sustained Release Systems
2. Controlled Release Systems
- Reservoir Systems
- Monolithic Systems
- Laminated Systems
- Chemical Systems
3. Targeted Drug Delivery Systems
- Local Targeted Delivery
- Differential Metabolism Approach
- Biological Recognition
- Biophysical Approach
- Prodrugs
4. Pulsatile Delivery Systems
For more
details, contact us at pharma@memeetings.com
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